Metabolomics
Metabolomics is the measurement of the full compliment of small molecules present in an organism, known as the metabolome. The approach uses mass spectrometry and high-field NMR spectroscopy in conjunction with chromatography techniques and multivariate statistical methods. These molecules include the components of the citric acid cycle, fatty acids, isoprenoids and steroids, ATP, phospholipids and many others involved in biochemical pathways.
Applications of metabolomics span the entire R&D value chain. They include the identifications of biomarkers for safety/toxicity, pharmacological activity, disease and drug efficacy, the prioritisation of compounds, or mechanism of action studies. A particular strength of this technology is the characterisation of phenotypes and metabolomics is commonly regarded as the best experimental method serving this purpose. Metabolomics is a powerful part of systems biology, providing data that are quantitative and more relevant. Selcia has applied metabolomics to the profiling of compounds and to support lead optimisation and clinical studies.
If you would like to discuss how our metabolomics services can help you please contact us.