The CEfrag Screen is a new technique for fragment-based screening. It uses capillary electrophoresis (CE) to detect weak binding interactions between your target and low molecular weight compounds (fragments). The technique is available to clients on a fee-for-service basis as a primary or orthogonal screening tool for rapid hit identification on your target. This robust, proven technology allows you to cost effectively kick-start your drug discovery project or to complement and strengthen your in-house hit generation programs.

We offer the options of running a fragment screening campaign on your target using our own fragment library, or of using your library or any commercial fragment collection.

• Solution phase binding assay based on affinity capillary electrophoresis
• Applicable to a broad range of targets
• No protein modification required
• Label-free technique
• Rapid assay development
• Micro scale technique
• Highly flexible: detects protein, ligand or protein-ligand complex
• Generation of IC₅₀ values
• Low false positive rate
• Validated against multiple targets
• Validated screening tool for detection of protein-protein interactions
• Suitable for use with microbial extracts
• Robust: tolerates DMSO and common additives such as detergents and salts