Nov 2015: Key milestones achieved on Wellcome SDDI project
Selcia and University of Edinburgh have successfully passed the 20-month milestone targets of a 30-month Wellcome Trust SDDi project to design novel treatments for sleeping sickness.
Nov 2015: Working with Cypralis on cyclophilin D inhibitors
Selcia’s spin out company Cypralis has been awarded co-funding by Innovate UK to generate a new class of cyclophilin inhibitors. Selcia will provide integrated drug discovery services to Cypralis including medicinal chemistry, PPIase screening and ADME.
June 2015: Selcia Renews Crédit d’Impôt Recherche (CIR)
Selcia has received renewal under the French Research Tax Credit scheme for the years 2015, 2016 and 2017.
Jan 2015: Stereochemistry of Teixobactin elucidated by Selcia
Selcia scientists have determined the absolute stereochemistry of the structure of teixobactin, a novel antibacterial macrocyclic peptide whose discovery is described in an article published in the journal Nature by NovoBiotic Pharmaceuticals.
Feb 2014: New collaboration with academia
The University of Edinburgh and Selcia join together to develop new drugs to combat sleeping sickness disease that threatens almost 70 million people in Africa. The new 30 month project is being funded by a £2.5 million grant from the Wellcome Trust.
Jan 2014: 69 full time staff employed
Nov 2013: Successful inspection of GMP facility
Selcia announces a successful inspection of its GMP radiochemistry facility by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA) and the granting of a new Good Manufacturing Practice (GMP) certificate for the preparation and 14C labelling of APIs.
Sep 2013: Cantab Anti-Infectives collaboration
A collaboration between Selcia and Cantab Anti-Infectives is agreed, the aim of which is to accelerate Cantab’s programme to develop improved antibiotics for multidrug resistant Gram-negative bacterial infections based on the polymyxin nucleus.
Nov 2012: Prolyl isomerase screening service launched
A new platform will focus drug discovery and development on the target family of peptidyl-prolyl cis-trans isomerases ("PPIases"). The new service encompasses drug screening and functional assays, and compound profiling.
Oct 2012: GLP re-certification
GLP re-certification is received for Selcia’s analytical laboratory following a successful Good Laboratory Practice (GLP) inspection by the UK Medicines and Healthcare products Regulatory Agency (MHRA).
Oct 2012: NeuroVive
Selcia’s Mitopharm subsidiary and Swedish drug development company NeuroVive Pharmaceutical AB announce the development of three lead drug candidates capable of increasing mitochondrial energy production with potential across a range of clinical conditions.
July 2012: Demerger announcement
Selcia announces the demerger of all internally generated intellectual property into two new subsidiary companies: Mitopharm and Cypralis.
June 2012: 20 year radiochemistry landmark
Anniversary celebrations are held at Selcia as the company marks twenty years of radiosynthesis at its headquarters in Ongar, UK.
April 2012: Research collaboration with Heptares Therapeutics
A new collaboration with Heptares aims to discover fragment ligands that specifically bind to a GPCR drug target purified by Heptares. Selcia will apply its novel CEfrag™ technology to confirm hits already obtained by Heptares and to screen its proprietary fragment library against the Heptares target.
November 2011: GMP certification leads to increased business
A significant increase in 14C radiolabelled API projects for phase 1 human trials follows MHRA GMP Certification in September. To deal with the upturn, investments are made to double capacity for handling GMP radiolabelling projects.
September 2011: Research collaboration with NeuroVive
A research collaboration is agreed with Swedish drug development company NeuroVive Pharmaceutical AB to develop new medicines and drug compounds targeting mitochondrial physiology and pathophysiology.
February 2011: Project with ExonHit Therapeutics
Successful completion of a drug discovery project with ExonHit Therapeutics SA (Paris, France). Novel and weak affinity hits were identified from Selcia’s fragment library, using the proprietary CEfrag™ technique. ExonHit Therapeutics advance viable hits for optimisation.
February 2011: Board appointments
Dr Andreas Rummelt is appointed as a Non-Executive Director.
December 2010: GMP certified
Selcia’s radiochemistry facility is granted a Good Manufacturing Practice (GMP) certificate for the preparation of C-14 labelled active pharmaceutical ingredients (APIs) following a successful inspection by the UK’s Medicines and Healthcare products Regulatory Agency (MHRA).
November 2010: Drug discovery collaboration with Convergence
Selcia and Convergence Pharmaceuticals, the latter a new company focused on the development of novel and high value analgesic medicines, announce a drug discovery collaboration to identify and develop high quality candidate molecules for the treatment of chronic pain.
November 2010: Supporting Gilead’s liver disease research
Integrated drug discovery services are used to support Gilead’s liver disease research programmes and is further proof of Selcia’s growing involvement in drug discovery.
February 2010: Radiochemistry developments in Japan
A custom 14-C radiolabelling service is established through agent Muromachi Chemicals Inc. of Tokyo. The move follows the company’s active participation in a UK Department of Trade and Industry trade mission to Tokyo the previous year. It signals Selcia’s commitment to developing its customer base in the Japanese radiolabelling market.
February 2010: Launch of Fragment Library
Following further technical development of Cetek’s fragment screening platform, Selcia launches CEfrag™ screen and a fragment library of approximately 1500 compounds.
January 2010: 60 full time staff employed
September 2009: Acquisition of fragment screening platform
A new fragment screening platform is unveiled following the acquisition of IP and expertise from Cetek Corporation. The move coincides with a brand and website relaunch designed to highlight Selcia’s integrated radiochemistry and drug discovery service.
April 2009: Further radiochemistry expansion
Construction of a further radiochemistry laboratory expands radiochemistry capacity to 30 fume cupboards.
August 2008: Expansion of radiochemistry facilities
Capacity increases by a third following installation of seven state-of-the-art synthesis hoods within newly refurbished laboratory space.
May 2008: GLP accreditation
Continued accreditation of the United Kingdom Good Laboratory Practice (GLP) Compliance Programme is achieved following inspection by the UK Medicines and Healthcare Products Regulatory Agency (MHRA).
May 2008: New recruits and facilities boost drug discovery capabilities
Discovery capabilities are boosted following the commissioning of a new biology unit and the recruitment of screening, enzymology and bio-analysis experts from several leading scientific institutes.
March 2008: Anti-inflammatory drug research grant awarded by EEDA
A £100k funding project by EEDA to evaluate anti-inflammatory activity of SEL-100130 coincides with the commissioning of a Class II containment cell biology facility. This first in-house joint biology - chemistry project signals the development of Selcia’s business model towards drug discovery.
January 2008: 48 full time staff employed
January 2006: Scynexis Europe renamed Selcia following MBO
Following the management buyout of Scynexis Europe by Dr Hans Fliri and the incumbent UK management team, the company is renamed Selcia. The company is the only dedicated provider of custom radiolabeling, chemistry and analytics services worldwide. Dr Fliri is appointed managing director. The newly named and independent company commences with 29 full time staff.
2001: Spin out from Aventis
Aventis’s Ongar facility is acquired by Scynexis Inc. The new subsidiary operation remains on the same site and is called Scynexis Europe. In addition to the existing radiochemistry expertise, Scynexis invests in automated high throughput drug discovery facilities.
1992: Establishment of radiochemistry services
Rhone Poulenc (renamed Aventis Crop Science in 1999) establishes a radiochemicals facility at what is now the Fyfield Research and Business Park, Ongar.