Techniques & Equipment

At Selcia we strive to be at the forefront of technological development in our sector. Constantly reviewing our skill portfolio we apply the latest techniques in organic synthesis and purification such as microwave-assisted reactions and chiral preparative HPLC to achieve the best possible results for our clients.

Our GLP analytical facility comprises an impressive array of instrumentation.

Our chemists are experienced in carrying out multi-step syntheses and have expertise with a broad range of different classes of compounds and reactions including

  • Modification of natural products (macrolide antibiotics, beta lactam antibiotics, anthracyclins, di- and triterpenes, steroids)
  • Aromatic and heterocyclic compounds
  • Lipids
  • Carbohydrates
  • Organometallic reactions (Grignard reactions, lithiations, cuprate reactions, Pd-chemistry, boron enolate chemistry, Wittig reactions, etc.)
  • Asymmetric synthesis & enantiomer separation (including preparative chiral HLPC)
  • Microwave assisted reactions

Our well-equipped GLP analytical laboratories features

  • NMR (300MHz, 400MHz, 500MHz)
  • Multinuclear Analysis (1H, 2H, 3H, 13C, 15N, 19F, 31P)
  • LC-MS Systems
  • LC-MS/MS System
  • Binary high pressure LC (capillary-LC capacity)
  • ESP, APcI
  • Micromass Platform – Binary high-pressure LC (capillary-LC capacity) offering Electrospray, APcI, EI and CI ion sources
  • Finnigan Aqa – Binary high-pressure LC (capillary-LC capacity) offering Electrospray and APcI ion sources

GC-MS System

  • Hewlett Packard with Gerstell Large volume PTV (biofluid analysis)

FT-IR Microscopy

  • Nicolet Protégé with Continuum Microscope
  • Diffuse reflectance

Radio isotope Analysis

  • TLC Instant Imagers, B-Imager, LS Counters