Crop Science Expertise

Our scientists have extensive industrial experience gained in leading agrochemical companies such as Bayer CropScience, Aventis CropScience, Rhone-Poulenc, May & Baker, FBC, Schering and AgrEvo.

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They have conducted synthesis chemistry research programmes leading to the discovery of many field candidates, development compounds and several commercial products as herbicides, fungicides and insecticides. Our analytical group have conducted the analytical component of environmental fate studies.

With core expertise in 14C radiolabelling, metabolite identification, impurity profiling and structural elucidation followed by synthesis of standards and GLP certification, we can support your CRO and regulatory submission and are familiar with working with regulatory affairs consultants.

Examples of our deep experience in both 14C radiolabelling and agrochemical discovery include, but are not limited to, the following accepted classes:

Herbicides

  • ALS Inhibitors e.g. Sulfonylureas and Imidazolinone (IMIs)
  • ACCase inhibitors e.g. Arloxyphenoxypropionates (FOPs) and Cyclohenane diones (Dims)
  • Photosystem II inhibitors e.g. Triazines, Ureas, Phenylcarbamates, Arylnitriles
  • HPPD inhibitors/bleachers e.g. Isoxaflutole, Diketonitriles
  • Phytoene desaturase inhibitors/bleachers e.g. Diflufenican
  • Chloroacetanilides and Oxyacetamides inhibitors of long chain fatty acid biosynthesis
  • Shikimate pathway inhibitors
  • Glutamine Synthetase inhibitors e.g. Glufosinate
  • PPO/Protox inhibitors
  • Hydroxy benzonitriles; HBNs
  • Auxins/Phenoxyacetic acids/Phenoxyproionic acids
  • Plant Growth regulators
  • Safeners

Insecticides

  • Acetylcholinesterase (AChE) inhibitors e.g. Organophosphares, Carbamates
  • Nicotinic acetylcholine receptor (nAChR) agonists e.g. Neonicotinoids
  • GABA-gated chloride channel antagonists e.g. Phenylpyrazoles
  • Sodium channel modulators e.g. Pyrethroids
  • Chloride channel activators e.g. Avermectins
  • Juvenile hormone mimics
  • Mite growth inhibitors e.g. Tetrazines
  • Inhibitors of mitochondrial electron transport e.g. Complex I inhibitors, Complex III inhibitors
  • Uncouplers of oxidative phosphorylation
  • Inhibitors of chitin biosynthesis e.g. Benzoyl ureas
  • Octopamine receptor agonists

Fungicides

  • Lanosterol C14-DMIs e.g. Azoles
  • Sterol Biosynthesis (Isomerase) Inhibitors e.g. Morpholines
  • Squalene epoxidae inhibotors e.g. Allyamines
  • Inhibitors of RNA polymerase e.g. Phenylalanaines
  • Inhibitors of electron transport complexes e.g. Strobilurins and related analogues (Complex III), Carboxamides (Complex II), Complex I inhibitors and uncouplers of oxidative phosphorylation
  • Methionine biosynthesis inhibitors e.g. Anilinopyrimidines
  • Melanin biosynthesis inhibitors
  • Dicarboxamide inhibitors of lipid peroxidation
  • MBCs and inhibitors of tubulin assembly