First class scientists and technology are the foundation of our successWe proactively evaluate and implement the latest technologies and recruit top scientists. This way we are able to add real value to our clients’ projects.

ADME/PK

High quality drug candidates are not possible without high quality data. We provide a comprehensive range of ADME, PK and bio-analytical services generating robust and reliable data.


Capabilities include:
 

  • pKa/ADME predictive tools
  • Physico-chemical properties (Log D, solubility, chemical stability)
  • Metabolic stability (in microsomes and/or plasma)
  • Distribution studies (plasma protein binding and PAMPA)
  • Drug-drug Interactions (Cytochrome P450 inhibition e.g. CYP3A4)
  • Cytotoxicity (e.g. HepG2)
  • Bioanalysis (e.g. Metabolite Identification)
  • In vivo pharmacokinetics (sub-contracted to a trusted and validated partner)

We work closely with you to develop an ADME program suited to your project. We have a flexible approach depending on your requirements and can modify protocols and develop custom assays in your preferred format.
 

 

Please contact us for further information. We will be pleased to arrange a teleconference or meeting with our technical experts.